A Transcriptome-wide Translational Program Defined by LIN28B Expression Level

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Wide application security by low-level program code obfuscation techniques

The goal of our research project is to protect security of applications and software systems in a whole new way: by diversifying implementations of all the software layers and their interfaces on the binary level. The system call interface of the operating system is diversified uniquely for each system and all the entry points to this interface are diversified in applications and libraries acco...

متن کامل

Algebras defined by homomorphisms

Let $mathcal{R}$ be a  commutative ring with identity, let $A$ and $B$ be two $mathcal{R}$-algebras and $varphi:Blongrightarrow A$ be an $mathcal{R}$-additive algebra homomorphism. We introduce a new algebra $Atimes_varphi B$, and give some basic properties of this algebra. Generalized $2$-cocycle derivations on $Atimes_varphi B$ are studied. Accordingly, $Atimes_varphi B$ is considered from th...

متن کامل

Transcriptome-wide Analysis of Roles for tRNA Modifications in Translational Regulation.

Covalent nucleotide modifications in noncoding RNAs affect a plethora of biological processes, and new functions continue to be discovered even for well-known modifying enzymes. To systematically compare the functions of a large set of noncoding RNA modifications in gene regulation, we carried out ribosome profiling in budding yeast to characterize 57 nonessential genes involved in tRNA modific...

متن کامل

Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing

Many disease-associated variants identified by genome-wide association (GWA) studies are expected to regulate gene expression. Allele-specific expression (ASE) quantifies transcription from both haplotypes using individuals heterozygous at tested SNPs. We performed deep human transcriptome-wide resequencing (RNA-seq) for ASE analysis and expression quantitative trait locus discovery. We reseque...

متن کامل

Genome-wide identification of chromosomal regions of increased tumor expression by transcriptome analysis.

Genes up-regulated in tumor cells provide attractive anticancer therapeutic targets. Although the general underlying mechanism for the increased expression in tumors is unknown, tumor-specific up-regulation of some genes can be attributed to aberrant DNA amplification, a phenomenon common to many tumors. Using a computational method, we constructed a general transcriptome map with the human gen...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Molecular Cell

سال: 2019

ISSN: 1097-2765

DOI: 10.1016/j.molcel.2018.10.041